Article

p38 MAPK fuels proliferation stress and DNA damage impairing the functionality of genetically engineered hematopoietic stem and progenitor cells

2023-07-27

Abstract excerpt

<title>Abstract</title> <p><italic>Ex vivo</italic> activation and cell cycle progression of hematopoietic stem and progenitor cells (HSPCs) is a prerequisite to reaching adequate levels of genetic engineering by homology-driven repair (HDR) for clinical applications. Here, we show that shortening <italic>ex vivo</italic> culture mitigates the p53-mediated DNA damage response initiated by the concomitant exposure...

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Literature Corpus work: 482ac372-43ca-50a9-a256-db1dbf21ddc6
DOI: 10.21203/rs.3.rs-3192507/v1

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