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NOTCH-mediated ex vivo expansion of human hematopoietic stem and progenitor cells by culture under hypoxia

26 Aug 2021

Abstract excerpt

[DXI]) has enabled ex vivo expansion of short-term HSPCs, but the effect on long-term repopulating hematopoietic stem cells (LTR-HSCs) remains uncertain. Here, we demonstrate that ex vivo culture of human adult HSPCs with DXI under low oxygen tension limits ER stress in LTR-HSCs and lineage-committed progenitors compared with normoxic cultures. A distinct HSC gene signature was upregulated in cells cultured with...

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PMID: 34450041
DOI: 10.1016/j.stemcr.2021.08.001

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