Article

Single-Cell Mapping of Malignant Signaling Networks Guides Drug Combinations

2026-08-18

Abstract excerpt

Single-cell breast cancer atlases reveal malignant, immune, and stromal diversity; however, how the recurrent signaling pathways drive untreated malignant-cell states and could inform combination therapy remains unclear. Here, we analyzed 15,753 malignant cells from untreated primary breast tumors using a cell-resolved network framework. Individual transcriptomes were projected onto a protein–protein interaction n...

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Literature Corpus work: d7bcab6d-7cb6-5265-8f4f-dd6d62e17cb1
DOI: 10.64898/2026.08.12.744506

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