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A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer

11 Apr 2019

Abstract excerpt

Breast cancer is a heterogeneous disease. Tumor cells and associated healthy cells form ecosystems that determine disease progression and response to therapy. To characterize features of breast cancer ecosystems and their associations with clinical data, we analyzed 144 human breast tumor and 50 non-tumor tissue samples using mass cytometry. The expression of 73 proteins in 26 million cells was evaluated using...

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PMID: 30982598
DOI: 10.1016/j.cell.2019.03.005

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