Article
Structural and calorimetric studies reveal specific determinants for the binding of a high-affinity NLS to mammalian importin-alpha.
The Biochemical journal - 16 Jul 2021
de Oliveira Hamine C, da Silva Tainá D, Salvador Guilherme H M, Moraes Ivan R, Fukuda Cíntia A, de Barros Andrea C, Fontes Marcos R M
Abstract excerpt
The classical nuclear import pathway is mediated by importin (Impα and Impβ), which recognizes the cargo protein by its nuclear localization sequence (NLS). NLSs have been extensively studied resulting in different proposed consensus; however, recent studies showed that exceptions may occur. This mechanism may be also dependent on specific characteristics of different Impα. Aiming to better understand the...
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