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Article

Promoter choice: Who should drive the CAR in T cells?

24 Jul 2020

Abstract excerpt

Chimeric antigen receptor (CAR) T cell therapy is an effective treatment for B cell malignancies, with emerging potential for the treatment of other hematologic cancers and solid tumors. The strength of the promoter within the CAR cassette will alter CAR-polypeptide levels on the cell surface of the T cell-impacting on the kinetics of activation, survival and memory cell formation in T cells. In addition to the...

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PMID: 32706785
DOI: 10.1371/journal.pone.0232915

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