Pathogenesis of kidney disease in systemic lupus erythematosus.

Abstract excerpt

PURPOSE OF REVIEW: A combination of systemic autoimmunity and tissue response to immune injury underlie renal involvement in lupus erythematosus. In this review, we discuss recent literature investigating pathogenetic mechanisms of lupus glomerulonephritis. RECENT FINDINGS: In lupus glomerulonephritis, glomerular immune complexes were believed to be the primary mediators of renal disease. Recent studies make it...

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