Article
The molecular functions of RIT1 and its contribution to human disease.
The Biochemical journal - 14 Aug 2020
Van Richard, Cuevas-Navarro Antonio, Castel Pau, McCormick Frank
Abstract excerpt
RIT1 is a member of the Ras family of GTPases that direct broad cellular physiological responses through tightly controlled signaling networks. The canonical Ras GTPases are well-defined regulators of the RAF/MEK/ERK pathway and mutations in these are pathogenic in cancer and a class of developmental disorders termed RASopathies. Emerging clinical evidences have now demonstrated a role for RIT1 in RASopathies,...
Topics
- Animals
- Disease Models, Animal
- Humans
- Mutation
- Neoplasms
- Noonan Syndrome
- ras Proteins