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Caudal Fgfr1 disruption produces localised spinal mis-patterning and a terminal myelocystocele-like phenotype in mice

2023-03-07

Abstract excerpt

Closed spinal dysraphisms are poorly understood neurodevelopmental malformations commonly classed as neural tube defects. Several, including terminal myelocystocele, selectively affect the distal lumbosacral spine. We previously identified a neural tube closure-initiating point, Closure 5, involved in forming the distal spine of mice. Here we document equivalent morphology of the caudal-most end of the closing pos...

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Literature Corpus work: d769d4e4-a9dc-5544-ab03-d054784ca0d3
DOI: 10.1101/2023.03.07.531511

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Caudal Fgfr1 disruption produces localised spinal mis-patterning and a terminal myelocystocele-like phenotype in miceDOI 10.1101/2023.03.07.531511Read

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Caudal <i>Fgfr1</i> disruption produces localised spinal mis-patterning and a terminal myelocystocele-like phenotype in mice

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