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Article

Caudal Fgfr1 disruption produces localised spinal mis-patterning and a terminal myelocystocele-like phenotype in mice.

Development (Cambridge, England) - 1 Oct 2023

Maniou Eirini, Farah Faduma, Marshall Abigail R, Crane-Smith Zoe, Krstevski Andrea, Stathopoulou Athanasia, Greene Nicholas D E, Copp Andrew J, Galea Gabriel L

Abstract excerpt

Closed spinal dysraphisms are poorly understood malformations classified as neural tube (NT) defects. Several, including terminal myelocystocele, affect the distal spine. We have previously identified a NT closure-initiating point, Closure 5, in the distal spine of mice. Here, we document equivalent morphology of the caudal-most closing posterior neuropore (PNP) in mice and humans. Closure 5 forms in a region of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37756583
DOI: 10.1242/dev.202139
PMCID: PMC10617625

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