Article

Repression of HIV-1 Reactivation Mediated By KRAB Fused CRISPR/dCas9 Proteins In Lymphoid And Myeloid Cell Models

2022-02-01

Abstract excerpt

<h4>Background: </h4> Despite antiretroviral treatment efficacy, it does not lead to the complete eradication of HIV infection. In addition, HIV-1 latency reactivation is a major challenge towards cure efforts. Two strategies to cure HIV-1 infection, the “shock and kill” is based on the eradication of the HIV-1 from the patient, and the “block and lock". The “Block and Lock” methodology aims to control HIV-1 laten...

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Literature Corpus work: d729a5ca-7533-5c57-90d1-0ab937dfea01
DOI: 10.21203/rs.3.rs-1241935/v1

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