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<i>Collagen-binding IL-12 expressing</i> STEAP1 CAR-T cells reduce toxicity and eradicate mouse prostate cancer in combination with checkpoint inhibitors

2025-03-19

Abstract excerpt

Immunosuppressive microenvironments, the lack of immune infiltration, and antigen heterogeneity pose significant challenges for chimeric antigen receptor (CAR)-T cell therapies to tackle solid tumors. CAR-T cells were armed with immunostimulatory payloads, such as interleukin-12 (IL-12), to overcome this issue, but faced intolerable toxicity during clinical development. Here, we show that collagen-binding domain-f...

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Literature Corpus work
d714947a-1d50-582d-88f6-666275920bed
DOI
10.1101/2025.03.19.644145
Open publication

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<i>Collagen-binding IL-12 expressing</i> STEAP1 CAR-T cells reduce toxicity and eradicate mouse prostate cancer in combination with checkpoint inhibitorsDOI 10.1101/2025.03.19.644145
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