Article

BET inhibition sensitizes immunologically-cold Rb-deficient prostate cancer to immune checkpoint blockade

2022-03-27

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Purpose</h4> Non-T cell-inflamed immunologically “cold” tumor microenvironments (TME) are associated with poor responsiveness to immune checkpoint blockade (ICB), and can be sculpted by tumor cell genomics. Here we evaluated how Retinoblastoma (Rb) tumor suppressor loss of function (LOF), one of the most frequent alterations in human cancer and associated with lineage plasticity, poor progn...

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Literature Corpus work: 2050f85f-409b-5f37-b7ce-243f5198f174
DOI: 10.1101/2022.03.24.485685

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