Article

Mucosal administration of lipid nanoparticles containing self-amplifying mRNA induces local uptake and expression in a pig model as a potential vaccination platform against STIs

2025-04-09

Abstract excerpt

<title>Abstract</title> <p>Mucosal vaccination generates protective immune responses directly at the primary site of STI infection. However, the delivery of nanoparticles is hindered by the mucus barrier at these mucosal surfaces. Due to this interference, research on mucosal administration of self-amplifying (sa)-mRNA encapsulated in lipid nanoparticles (LNP) is currently limited and inconsistent. Some progress...

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Literature Corpus work: d70bf906-b576-5f14-8829-b375369d68d3
DOI: 10.21203/rs.3.rs-5682423/v1

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