Article

<i>Ex vivo</i> recapitulation of intramuscular mRNA vaccination with naïve and recall antigens using a human Lymphoid Follicle Chip platform

2025-04-17

Abstract excerpt

<h4>Summary</h4> Predicting the efficacy and toxicity of intramuscular mRNA vaccines remains challenging. Here, we describe an ex vivo human cell-based model that replicates immune responses to lipid nanoparticle (LNP)-based mRNA vaccines that require intramuscular injection. Vaccines are administered into a biomimetic muscle module containing human skeletal myoblasts and antigen-presenting cells (APCs) to mimic...

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Literature Corpus work: ac9ffa53-a169-53cf-9fa5-ebb5ec3823f0
DOI: 10.1101/2025.04.16.649172

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