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A self-amplifying mRNA vaccine expressing PRV gD induces robust immunity against virulent mutants

14 Aug 2025

Abstract excerpt

Pseudorabies virus (PRV) causes an acute febrile infectious disease of pigs. Since 2011, PRV variants have appeared and spread nationwide in China. mRNA vaccines present a safe alternative and can stimulate humoral and cellular immunity. We constructed a self-amplifying mRNA (saRNA) vaccine containing gD gene of a highly virulent PRV variant. In mice, the PRV saRNA gD vaccine induced high levels of neutralizing...

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PMID: 40813770
DOI: 10.1038/s41541-025-01251-5

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