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A Lassa virus mRNA vaccine confers protection but does not require neutralizing antibody in a guinea pig model of infection

12 Sept 2023

Abstract excerpt

Lassa virus is a member of the Arenaviridae family, which causes human infections ranging from asymptomatic to severe hemorrhagic disease with a high case fatality rate. We have designed and generated lipid nanoparticle encapsulated, modified mRNA vaccines that encode for the wild-type Lassa virus strain Josiah glycoprotein complex or the prefusion stabilized conformation of the Lassa virus glycoprotein complex....

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PMID: 37699929
DOI: 10.1038/s41467-023-41376-6

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