Article

The Preclinical Evaluation of Self-Replicating RNA Oral Vaccine to Simultaneously Neutralize Both SARS-CoV-2 Delta and Alpha Variants

2021-08-05

Abstract excerpt

The aim of this study was to design an oral vaccine based on self-replicating RNA lipid nanoparticle (saRNA LNP) to neutralize SARS-CoV-2 Delta (B.1.617 lineage) and Alpha (B.1.1.7 lineage) variants. Before immunization of mice with saRNA LNP, we saw the high expression of S-protein at both mRNA and protein levels after transfection of HEK293T/17 with saRNA LNP. After immunization of BALB/c mice with saRNA LNP at...

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Literature Corpus work: ee5b028f-9af1-5409-a72f-574c4e2f7183
DOI: 10.21203/rs.3.rs-753957/v1

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