Back to search

Article

A piezoelectric electroporator (Piezopen) for enhanced “naked” RNA vaccine delivery

2025-02-08

Abstract excerpt

Despite the success of COVID-19 mRNA vaccines, they still face challenges with high costs, complex manufacturing, off-target biodistribution, and systemic reactogenicity stemming from their inflammatory carriers: lipid nanoparticles (LNPs). While “naked” RNA delivery could in principle solve these issues, studies have suggested that it is infeasible due to rapid degradation by RNases and poor cellular entry, there...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
14922db7-a22f-5083-82f1-209ee9cf2798
DOI
10.1101/2025.02.07.637103
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A piezoelectric electroporator (Piezopen) for enhanced “naked” RNA vaccine deliveryDOI 10.1101/2025.02.07.637103
Progress and challenges of mRNA vaccinesSemantic proximity
From COVID-19 to Global Health: Challenges and Opportunities in mRNA Vaccine ProductionSemantic proximity
mRNA Vaccines Five Years After COVID-19: Lessons in Platform Design, Real-World Effectiveness, and EquitySemantic proximity
Lipid Nanoparticle Delivery Systems to Enable mRNA-Based TherapeuticsSemantic proximity
mRNA Vaccine Platforms and Lipid Nanoparticle Delivery Systems: Molecular Advances, Clinical Breakthroughs, and Regulatory Perspectives (2020–2025)Semantic proximity
Ultrasonic particles: An approach for targeted gene deliverySemantic proximity
Enhancing Cytoplasmic Expression of Exogenous mRNA through Dynamic Mechanical StimulationSemantic proximity
Mucosal mRNA Vaccines. Merits and PerspectivesSemantic proximity
The Unique Features and Collateral Immune Effects of mRNA-Based COVID-19 Vaccines: Potential Plausible Causes of Adverse Events and ComplicationsSemantic proximity
Lipid nanoparticles in the development of mRNA vaccines for COVID-19Semantic proximity
Electro-mechanical transfection for non-viral primary immune cell engineeringSemantic proximity
Harnessing Recent Advances in Synthetic DNA and Electroporation Technologies for Rapid Vaccine Development Against COVID-19 and Other Emerging Infectious DiseasesSemantic proximity
Select a neighboring publication to make it the new centre.