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Human breast milk-derived exosomes attenuate lipopolysaccharide-induced upregulation of CD40 and NLRP3 in microglia

2024-10-11

Abstract excerpt

<title>Abstract</title> <p>Microglia mediate the immune response in the central nervous system to many insults, including lipopolysaccharide (LPS), a bacterial endotoxin that initiates neuroinflammation in the neonatal population, especially preterm infants. The synthesis of the proinflammatory proteins CD40 and NLRP3 depends on the canonical ΝF-κΒ cascade as the genes encoding CD40 and NLRP3 are transcribed by t...

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Literature Corpus work
d6d5e405-a810-537b-9d24-b7ee7b8550bc
DOI
10.21203/rs.3.rs-4818836/v1
Open publication

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Human breast milk-derived exosomes attenuate lipopolysaccharide-induced upregulation of CD40 and NLRP3 in microgliaDOI 10.21203/rs.3.rs-4818836/v1
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