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Article

N-cadherin upregulation mediates adaptive radioresistance in glioblastoma

14 Mar 2021

Abstract excerpt

Glioblastoma (GBM) is composed of heterogeneous tumor cell populations, including those with stem cell properties, termed glioma stem cells (GSCs). GSCs are innately less radiation sensitive than the tumor bulk and are believed to drive GBM formation and recurrence after repeated irradiation. However, it is unclear how GSCs adapt to escape the toxicity of repeated irradiation used in clinical practice. To...

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PMID: 33720050
DOI: 10.1172/jci136098

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