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Article

The histone demethylase KDM5A is a key factor for the resistance to temozolomide in glioblastoma.

Cell cycle (Georgetown, Tex.) - 1 Jan 2015

Banelli Barbara, Carra Elisa, Barbieri Federica, Würth Roberto, Parodi Federica, Pattarozzi Alessandra, Carosio Roberta, Forlani Alessandra, Allemanni Giorgio, Marubbi Daniela, Florio Tullio, Daga Antonio, Romani Massimo

Abstract excerpt

Notwithstanding current multimodal treatment, including surgery, radiotherapy and chemotherapy with temozolomide (TMZ), median survival of glioblastoma (GBM) patients is about 14 months, due to the rapid emergence of cell clones resistant to treatment. Therefore, understanding the mechanisms underlying chemoresistance is mandatory to improve treatments' outcome. We generated TMZ resistant cells (TMZ-R) from a GBM...

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Identifiers

PMID: 26566863
DOI: 10.1080/15384101.2015.1090063
PMCID: PMC4825557

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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