Article

In vivo spatial coordination with synthetic paracrine signaling

2026-06-29

Abstract excerpt

<h4>ABSTRACT</h4> The immune system uses paracrine signaling to spatially confine potent responses such as inflammation. A bio-orthogonal synthetic paracrine system could enable engineering of analogous multicellular circuits in which different cell types coordinate their functions in a spatially organized fashion. Here, using the plant hormone auxin as a bio-orthogonal chemical signal, we introduce programmable...

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Literature Corpus work: d6d35d21-9f2e-5c0a-85ec-996bde4b1340
DOI: 10.64898/2026.06.26.734902

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