Article

Engineering self-propelled tumor-infiltrating CAR T cells using synthetic velocity receptors

2023-12-14

Abstract excerpt

<h4>ABSTRACT</h4> Chimeric antigen receptor (CAR) T cells express antigen-specific synthetic receptors, which upon binding to cancer cells, elicit T cell anti-tumor responses. CAR T cell therapy has enjoyed success in the clinic for hematological cancer indications, giving rise to decade-long remissions in some cases. However, CAR T therapy for patients with solid tumors has not seen similar success. Solid tumors...

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Literature Corpus work: 3dcf6695-24f6-5307-9216-ff7870046f60
DOI: 10.1101/2023.12.13.571595

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