Article

Systematic Discovery of Antibacterial and Antifungal Bacterial Toxins

2021-10-19

Abstract excerpt

Microbes employ toxins to kill competing microbes or eukaryotic host cells. Polymorphic toxins are proteins that encode C-terminal toxin domains. Here, we developed a computational approach to discover novel toxin domains of polymorphic toxins within 105,438 microbial genomes. We validated nine short novel toxins (“PTs”) that cause bacterial or yeast cell death. The novel PTs are encoded by ∼2.2% of the sequenced...

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Literature Corpus work: 6bf9bcf9-76d3-53f3-bb8d-72f5cbf7f2be
DOI: 10.1101/2021.10.19.465003

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