Article

Parkinson’s Disease: Cells Succumbing to Lifelong Dopamine-related Oxidative Stress and Other Bioenergetic Challenges

2024-01-03

Abstract excerpt

The core pathological event in Parkinson’s disease (PD) is the specific dying of dopamine (DA) neurons of the substantia nigra pars compacta (SNc). Why SNc DA neurons are especially vulnerable and why idiopathic PD has only been found in humans is still puzzling. The two main underlying factors of SNc DA neuron vulnerability appear related to high DA production, namely (i) the toxic effects of cytoplasmic DA metab...

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Literature Corpus work: cd806731-dd5a-5fd4-a6b8-d816b112f2bc
DOI: 10.20944/preprints202401.0245.v1

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