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Article

Mitochondria, calcium and cell death: a deadly triad in neurodegeneration.

Biochimica et biophysica acta - 1 May 2009

Celsi Fulvio, Pizzo Paola, Brini Marisa, Leo Sara, Fotino Carmen, Pinton Paolo, Rizzuto Rosario

Abstract excerpt

Mitochondrial Ca(2+) accumulation is a tightly controlled process, in turn regulating functions as diverse as aerobic metabolism and induction of cell death. The link between Ca(2+) (dys)regulation, mitochondria and cellular derangement is particularly evident in neurodegenerative disorders, in which genetic models and environmental factors allowed to identify common traits in the pathogenic routes. We will here...

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Identifiers

PMID: 19268425
DOI: 10.1016/j.bbabio.2009.02.021
PMCID: PMC2696196

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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