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Decoding Parkinson's Disease: The interplay of cell death pathways, oxidative stress, and therapeutic innovations

23 Jul 2025

Abstract excerpt

Parkinson’s disease (PD), a complex neurodegenerative disorder characterized by selective loss of substantia nigra (SN) dopaminergic neurons, pathological aggregation of α-synuclein (α-syn), and chronic neuroinflammation, is fundamentally driven by redox imbalance and oxidative stress. Recent studies reveal that a dynamic interplay of programmed and non-programmed cell death mechanisms—amplified by oxidative...

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PMID: 40712453
DOI: 10.1016/j.redox.2025.103787

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