Article

Deep Phenotyping of the Lipidomic Response in COVID and non-COVID Sepsis

2023-06-02

Abstract excerpt

Lipids may influence cellular penetrance by pathogens and the immune response that they evoke. Here we find a broad based lipidomic storm driven predominantly by secretory (s) phospholipase A 2 (sPLA 2 ) dependent eicosanoid production occurs in patients with sepsis of viral and bacterial origin and relates to disease severity in COVID-19. Elevations in the cyclooxygenase (COX) products of arachidonic acid (AA),...

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Literature Corpus work: d6854c59-be1c-56e0-a197-2df60b7c4b46
DOI: 10.1101/2023.06.02.543298

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