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Article

In Vivo RNA Interference Models of Inducible and Reversible Sirt1 Knockdown in Kidney Cells

18 Jun 2014

Abstract excerpt

The silent mating type information regulation 2 homolog 1 gene (Sirt1) encodes an NAD-dependent deacetylase that modifies the activity of well-known transcriptional regulators affected in kidney diseases. Sirt1 is expressed in the kidney podocyte, but its function in the podocyte is not clear. Genetically engineered mice with inducible and reversible Sirt1 knockdown in widespread, podocyte-specific, or...

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PMID: 24952428
DOI: 10.1016/j.ajpath.2014.03.016

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