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Article

A Helical Membrane‐Binding Domain Targets the <i>Toxoplasma</i> ROP2 Family to the Parasitophorous Vacuole

22 Jun 2009

Abstract excerpt

During invasion, the obligate intracellular pathogen, Toxoplasma gondii, secretes into its host cell a variety of effector molecules, several of which have been implicated in strain-specific variation in disease. The largest family of these effectors, defined by the canonical member ROP2, quickly associates with the nascent parasitophorous vacuole membrane (PVM) after secretion. Here we demonstrate that the...

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PMID: 19682324
DOI: 10.1111/j.1600-0854.2009.00958.x

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