Regulated expression of the <i>Leishmania major</i> surface virulence factor lipophosphoglycan using conditionally destabilized fusion proteins

Abstract excerpt

Surface glycoconjugates play important roles in the infectious cycle of Leishmania major, including the abundant lipophosphoglycan (LPG) implicated in parasite survival in the sand fly vector and the initial stages of establishment in the mammalian host macrophage. We describe a system for inducible expression of LPG, applying a novel protein-based system that allows controlled degradation of a key LPG...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Research on Leishmaniasis Studies
• Share to Signaling Pathways in Disease
• Share to Trypanosoma species research and implications