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Integration of multiple networks and pathways identifies cancer driver genes in pan-cancer analysis

5 Jan 2018

Abstract excerpt

BACKGROUND: Modern high-throughput genomic technologies represent a comprehensive hallmark of molecular changes in pan-cancer studies. Although different cancer gene signatures have been revealed, the mechanism of tumourigenesis has yet to be completely understood. Pathways and networks are important tools to explain the role of genes in functional genomic studies. However, few methods consider the functional...

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PMID: 29304754
DOI: 10.1186/s12864-017-4423-x

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