Article

Ketamine’s pharmacogenomic network in human brain contains sub-networks associated with glutamate neurotransmission and with neuroplasticity

2020-04-30

Abstract excerpt

The pharmacogenomic network responsible for the rapid antidepressant action of ketamine and concomitant adverse events in patients has been poorly defined. Integrative, multi-scale biological data analytics helps explain ketamine’s action. Using a validated computational pipeline, candidate ketamine-response genes and regulatory RNAs from published literature, binding affinity studies, and single nucleotide polymo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d653f43f-79ee-5d78-acca-b86c51601282
DOI: 10.1101/2020.04.28.053587

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ketamine’s pharmacogenomic network in human brain contains sub-networks associated with glutamate neurotransmission and with neuroplasticityDOI 10.1101/2020.04.28.053587Read

A brain splicing-QTL colocalization map of candidate effector genes for major depressive disorderSemantic proximity Read

Identifying Potential Novel Pathways and Therapeutic Targets of Major Depressive Disorder with Functional GenomicsSemantic proximity Read

Methylome and transcriptome functional analysis identifies key biomarkers in ketamine’s sustained therapeutic effect on PTSDSemantic proximity Read

Ketamine induces synaptic and monoaminergic remodeling in human iPSC-derived neuronsSemantic proximity Read

Transcriptional profiling of antidepressant ketamine and electroconvulsive therapy treatmentSemantic proximity Read

A conserved BDNF, glutamate- and GABA-enriched gene module related to human depression identified by coexpression meta-analysis and DNA variant genome-wide association studies.Semantic proximity Read

The Converging Effects of Different Categories of Antidepressants on the Brain: A Systematic Meta-Analysis of Public Transcriptional Profiling Data from the Hippocampus and CortexSemantic proximity Read

Brain-epigenome wide association study (BEWAS) on the effects of two emerging psychedelics: ketamine & MDMASemantic proximity Read

Role of the Pharmacogenomics in the Treatment-Resistant Depression: A Literature ReviewSemantic proximity Read

Genome-wide association study and polygenic risk score analysis of esketamine treatment response.Semantic proximity Read

A glutamatergic network mediates lithium response in bipolar disorder as defined by epigenome pathway analysis.Semantic proximity Read

Identifying drug targets for neurological and psychiatric disease via genetics and the brain transcriptome.Semantic proximity Read