Article

A brain splicing-QTL colocalization map of candidate effector genes for major depressive disorder

2026-08-07

Abstract excerpt

<title>Abstract</title> <p>Genetic risk for major depressive disorder (MDD) can act through gene expression or pre-mRNA alternative splicing, but effector-gene mapping has relied mainly on expression quantitative trait loci (eQTLs), leaving splicing-level effects less systematically resolved. We integrated the latest MDD GWAS (MDD2025; effective sample size ~ 1.15×10⁶) with BigBrain, a human-brain cis-splicing-QT...

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Literature Corpus work: 356b08cc-a4b1-5c79-86ed-8cc238a78436
DOI: 10.21203/rs.3.rs-10366398/v1

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