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Transcriptional profiling of antidepressant ketamine and electroconvulsive therapy treatment

2025-07-29

Abstract excerpt

1. <h4>Background</h4> Treatment-resistant depression (TRD) affects 30-50% of patients with major depressive disorder (MDD). Electroconvulsive therapy (ECT) and sub-anesthetic ketamine treatment can relieve TRD, yet their antidepressant mechanisms remain unclear. Peripheral blood gene expression offers a non-invasive proxy to examine potential treatment-response biomarkers. <h4>Methods</h4> We conducted a transc...

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Literature Corpus work
1c08360f-1f53-5c2e-9644-3e7f6826096a
DOI
10.1101/2025.07.29.25332162
Open publication

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Transcriptional profiling of antidepressant ketamine and electroconvulsive therapy treatmentDOI 10.1101/2025.07.29.25332162
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