Article

Simple cell geometry metrics reveal cancer cell diversity and plasticity and guide combination therapy

2026-01-09

Abstract excerpt

<title>Abstract</title> <p>Intra-tumour heterogeneity (ITH) and cellular plasticity contribute to therapy resistance. Single-cell transcriptomics is the gold standard for assessing ITH, but this approach remains costly and slow. Here, we show that distinct melanoma transcriptomic states exhibit unique cellular morphologies, and introduce ORIGAMI, a scalable flow cytometry assay leveraging cell surface area (S) an...

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Literature Corpus work: d640d4bd-d30f-5b50-8e70-3bbf43b4f124
DOI: 10.21203/rs.3.rs-8278743/v1

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