Morphological profiling by high-throughput single-cell biophysical fractometry

Abstract excerpt

Complex and irregular cell architecture is known to statistically exhibit fractal geometry, i.e., a pattern resembles a smaller part of itself. Although fractal variations in cells are proven to be closely associated with the disease-related phenotypes that are otherwise obscured in the standard cell-based assays, fractal analysis with single-cell precision remains largely unexplored. To close this gap, here we de...

Topics

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• Algorithms
• Apoptosis
• Autophagy
• Cell Nucleus
• Cell Size
• Cellular Senescence
• Image Processing, Computer-Assisted
• Phenotype

Identifiers and source

Literature Corpus work

ad21ed30-0605-5ff4-a9ee-d8cdc83fd1fe

DOI

10.1101/2022.05.24.493226