Article
Linking the genotypes and phenotypes of cancer cells in heterogenous populations via real-time optical tagging and image analysis.
Nature biomedical engineering - 1 May 2022
You Li, Su Pin-Rui, Betjes Max, Rad Reza Ghadiri, Chou Ting-Chun, Beerens Cecile, van Oosten Eva, Leufkens Felix, Gasecka Paulina, Muraro Mauro, van Tol Ruud, van Steenderen Debby, Farooq Shazia, Hardillo Jose Angelito U, de Jong Robert Baatenburg, Brinks Daan, Chien Miao-Ping
Abstract excerpt
Linking single-cell genomic or transcriptomic profiles to functional cellular characteristics, in particular time-varying phenotypic changes, could help unravel molecular mechanisms driving the growth of tumour-cell subpopulations. Here we show that a custom-built optical microscope with an ultrawide field of view, fast automated image analysis and a dye activatable by visible light enables the screening and...
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