Article

Programmable chronogenetic gene circuits for self-regulated circadian delivery of biologic drugs

2025-03-15

Abstract excerpt

Cells of the body rely on the circadian clock to orchestrate daily changes in physiology that impact both homeostatic and pathological conditions, such as the inflammatory autoimmune disease rheumatoid arthritis (RA). In RA, high levels of proinflammatory cytokines peak early in the morning hours, reflected by daily changes in joint stiffness. Chronotherapy (or circadian medicine) seeks to delivery drugs at optima...

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Literature Corpus work: d63ed312-4584-50be-b2b8-592af138cfd7
DOI: 10.1101/2025.03.14.643274

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