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A Synthetic Gene Circuit for Self-Regulating Delivery of Biologic Drugs in Engineered Tissues

10 Apr 2019

Abstract excerpt

Transient, resolving inflammation plays a critical role in tissue repair and regeneration. In the context of joint disease, however, chronic inflammation following injury or with osteoarthritis can lead to irreversible articular cartilage degradation and joint pain. Developing tissue engineering strategies for the regeneration of articular cartilage remains challenging due to the harsh inflammatory environment of...

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PMID: 30968743
DOI: 10.1089/ten.tea.2019.0027

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