Article

A Genome-engineered Bioartificial Implant for Autoregulated Anti-Cytokine Drug Delivery

2019-01-30

Abstract excerpt

Biologic drug therapies are effective treatments for autoimmune diseases such as rheumatoid arthritis (RA) but may cause significant adverse effects, as they are administered continuously at high doses that can suppress the immune system. Using CRISPR-Cas9 genome editing, we engineered stem cells containing a synthetic gene circuit expressing biologic drugs to antagonize interleukin-1 (IL-1) or tumor necrosis fact...

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Literature Corpus work: 2a49ac6f-6566-55c1-81ca-882760db2b8e
DOI: 10.1101/535609

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