Article

NLRP3 Inflammasome Up-Regulates Major Histocompatibility Complex Class I Expression and Promotes Inflammatory Infiltration in Polymyositis

2021-07-23

Abstract excerpt

<h4>Backgrounds: </h4>: This study was designed to investigate the role of the nucleotide-binding-domain (NBD)-and leucine-rich repeat (LRR)-containing (NLR) family, pyrin-domain-containing 3 (NLRP3) inflammasome in the pathogenesis of polymyositis (PM). <h4>Results: </h4>: We found that the percentage of CD68+ cells, and the expression levels of NLRP3, caspase-1 and interleukin-1 beta (IL-1β) in the muscle tissue...

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Identifiers and source

Literature Corpus work: d61a33af-a021-5229-a570-b85f85328171
DOI: 10.21203/rs.3.rs-728456/v1

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