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NLRP3 Inflammasome Activation and Altered Mitophagy Are Key Pathways in Inclusion Body Myositis

26 Dec 2024

Abstract excerpt

BACKGROUND: Inclusion body myositis (IBM) is the most prevalent muscle disease in adults for which no current treatment exists. The pathogenesis of IBM remains poorly defined. In this study, we aimed to explore the interplay between inflammation and mitochondrial dysfunction in IBM. METHODS: The study population consisted of 38 IBM patients and 22 age- and sex-matched controls without a myopathy. Mean age was...

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PMID: 39723571
DOI: 10.1002/jcsm.13672

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