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Article

Downregulation of the NLRP3 inflammasome by adiponectin rescues Duchenne muscular dystrophy

20 Mar 2018

Abstract excerpt

BACKGROUND: The hormone adiponectin (ApN) exerts powerful anti-inflammatory effects on skeletal muscle and can reverse devastating myopathies, like Duchenne muscular dystrophy (DMD), where inflammation exacerbates disease progression. The NLRP3 inflammasome plays a key role in the inflammation process, and its aberrant activation leads to several inflammatory or immune diseases. Here we investigated the...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 29558930
DOI: 10.1186/s12915-018-0501-z

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