Article

Regulation of alternative polyadenylation isoforms of <i>Timp2</i> is an effector event of RAS signaling in cell transformation

2024-09-26

Abstract excerpt

<h4>SUMMARY</h4> Alternative polyadenylation (APA) generates mRNA isoforms with different lengths of the 3’ untranslated region (3’ UTR). The tissue inhibitor of metalloproteinase 2 (TIMP2) plays a key role in extracellular matrix remodeling under various developmental and disease conditions. Both human and mouse genes encoding TIMP2 contain two highly conserved 3’UTR APA sites, leading to mRNA isoforms that diff...

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Literature Corpus work: d60e336a-eb88-5dd4-8653-f2b27cac44a3
DOI: 10.1101/2024.09.26.613909

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