Translational Repression of Human Matrix Metalloproteinases-13 by an Alternatively Spliced Form of T-cell-restricted Intracellular Antigen-related Protein (TIAR)

Abstract excerpt

Human matrix metalloproteinases-13 (HMMP13) shows a wide substrate specificity, and its expression is limited to pathological situations such as chronic inflammation and cancer. The coding sequence for HMMP13 is 86% identical to rat matrix metalloproteinases-13 (RMMP13); however, the regulation of HMMP13 and RMMP13 protein synthesis in renal mesangial cells is strikingly different. In human cells there is a...

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