Article
Alternative polyadenylation of cyclooxygenase-2.
Nucleic acids research - 1 Jan 2005
Hall-Pogar Tyra, Zhang Haibo, Tian Bin, Lutz Carol S
Abstract excerpt
A biologically important human gene, cyclooxygenase-2 (COX-2), has been proposed to be regulated at many levels. While COX-1 is constitutively expressed in cells, COX-2 is inducible and is upregulated in response to many signals. Since increased transcriptional activity accounts for only part of the upregulation of COX-2, we chose to explore other RNA processing mechanisms in the regulation of this gene. We...
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