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Article

Rational design of HER2-targeted combination therapies to reverse drug resistance in fibroblast-protected HER2+ breast cancer cells

2024-05-19

Abstract excerpt

<h4>Introduction</h4> Fibroblasts, an abundant cell type in the breast tumor microenvironment, interact with cancer cells and orchestrate tumor progression and drug resistance. However, the mechanisms by which fibroblast-derived factors impact drug sensitivity remain poorly understood. Here, we develop rational combination therapies that are informed by proteomic profiling to overcome fibroblast-mediated therapeu...

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Literature Corpus work
d608e1c5-c7e8-573b-900e-de0312d49b53
DOI
10.1101/2024.05.18.594826
Open publication

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Rational design of HER2-targeted combination therapies to reverse drug resistance in fibroblast-protected HER2+ breast cancer cellsDOI 10.1101/2024.05.18.594826
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