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Article

Selective impact of ALK and MELK inhibition on ERα stability and cell proliferation in cell lines representing distinct molecular phenotypes of breast cancer.

Scientific reports - 8 Apr 2024

Bartoloni Stefania, Pescatori Sara, Bianchi Fabrizio, Cipolletti Manuela, Acconcia Filippo

Abstract excerpt

Breast cancer (BC) is a leading cause of global cancer-related mortality in women, necessitating accurate tumor classification for timely intervention. Molecular and histological factors, including PAM50 classification, estrogen receptor α (ERα), breast cancer type 1 susceptibility protein (BRCA1), progesterone receptor (PR), and HER2 expression, contribute to intricate BC subtyping. In this work, through a...

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Share to Cell Proliferation
Share to Drug Resistance, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Estrogen Receptor alpha

Share to Gene Expression Regulation, Neoplastic

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Source

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Identifiers

PMID: 38589728
DOI: 10.1038/s41598-024-59001-x
PMCID: PMC11001865

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